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Cavernous hemangioma-like Kaposi sarcoma: Histomorphologic features and differential diagnosis

Onak Kandemir N. | Barut F. | Dogan Gün B. | Solak Tekin N. | Hallaç Keser S. | Oguz Özdamar Ş.

Makale | 2013 | Case Reports in Medicine2013

Aim. Cavernous hemangioma-like Kaposi sarcoma is a rare morphologic type of Kaposi sarcoma. So far there are no cases in the literature defining the histological features of this morphologic spectrum in detail. In this study we presented two classical-type cutaneous Kaposi sarcoma cases with histologic findings resembling cavernous hemangioma in company with clinical and histopathological data. Cases. One hundred and eighty-five classical-type cutaneous Kaposi sarcoma lesions in 79 patients were assessed retrospectively in terms of histopathological features. Findings of two cases showing features of cavernous hemangioma-like Kaposi . . . sarcoma whose clinical data could be accessed were presented in accompany with the literature data. Both cases were detected to have bluish-purple, protruded, irregularly bordered cutaneous lesions. Histopathological examination revealed a lesion formed by cavernous hemangioma-like vascular structures organized in a lobular pattern that became dilated and filled with blood. Typical histological findings of early-stage KS, consisting of mononuclear inflammation, extravasated erythrocytes, and a few immature vascular structures in superficial dermis, were observed. All cases were serologically HIV-1 negative. A positive reaction with HHV-8, CD31, CD34, and D2-40 monoclonal antibodies was identified at both cavernous hemangioma-like areas and in immature vascular structures. Results. Cavernous hemangioma-like Kaposi sarcoma is a rare Kaposi sarcoma variant presenting with diagnostic challenges, that may be confused with hemangioma. As characteristic morphological features may not be observed in every case, it is important for diagnostic purposes to show immunohistochemical HHV-8 positivity in this variant. © 2013 Nilüfer Onak Kandemir et al Daha fazlası Daha az

Ovarian heterotopic pregnancy clinically mimicking endometrioma

Onak Kandemir N. | Barut F. | Yurdakan G. | Bayar Ü. | Özdamar Ş.O.

Makale | 2010 | Turk Patoloji Dergisi/Turkish Journal of Pathology26 ( 1 ) , pp.85 - 88

Heterotopic pregnancy is a very uncommon entity with a difficult preoperative diagnosis. In the present study, we presented an ovarian heterotopic pregnancy case, clinically mimicking endometrioma developed in a 33-year-old female following an in vitro fertilization procedure. The importance of clinical, histopathological, and immunohistochemical examinations in the diagnosis of heterotopic pregnancy are emphasized.

Urothelial neoplasm of pelvis renalis with cytomorphology findings [Sitomorfolojik bulgularla pelvis renalisin üroteryal neoplazmi]

Barut F. | Kertiş G. | Bahadir B. | Özdamar S.O. | Gün B.D. | Seçkiner I. | Kuzey G.M.

Makale | 2009 | Journal of Experimental and Clinical Medicine (Turkey)26 ( 2 ) , pp.96 - 98

A case of langerhans cell histiocytosis with multisystemic involvement in an adult patient

Demirel B.G. | Tekin N.S. | Barut F. | Aslaner M. | Koca R. | Gencer D.

Makale | 2016 | Erciyes Tip Dergisi38 ( 2 ) , pp.78 - 80

Langerhans cell histiocytosis (LCH) is a rare group of idiopathic diseases characterized by abnormal proliferation of bone marrow-derived dendritic cells called histiocytes. It is more common in childhood, but in the literature, some adult cases have been reported. For several reasons, the disease is more familiar to pediatricians than it is to physicians handling adult cases; therefore, the diagnosis of adult cases is often delayed or missed. The clinical course of LCH is variable, ranging from a self-healing solitary bone lesion to a widely disseminated life-threatening disease. The diagnosis of LCH should be based on histologic a . . .nd immunophenotypic examination of perilesional skin. In this report, we present a case of LCH in a 66-yearold woman with bone, skin, and pituitary gland involvement; this case emphasizes that a patient with LCH should undergo careful multidisciplinary evaluation. © 2016 by Erciyes University School of Medicine Daha fazlası Daha az

Laser treatment of an oral squamous papilloma in a pediatric patient: A case report

Misir A. | Demiriz L. | Barut F.

Makale | 2013 | Journal of Indian Society of Pedodontics and Preventive Dentistry31 ( 4 ) , pp.279 - 281

Oral squamous papilloma is a benign proliferation of the stratified squamous epithelium, which results in a papillary or verrucous exophytic mass induced by human papilloma virus (HPV). These oral mucosa lesions are most often asymptomatic and have small progression. Laser assisted surgery is common nowadays with several advantages including successful hemostasis, devoid of sutures, wound sterilization and minimal post-operative pain and edema. The aim of this report is to present the oral squamous papilloma in a pediatric patient and its treatment with soft tissue laser. The lesion was excised with diode laser and the healing was u . . .neventful in follow-up visit after one year. Oral squamous papillomas can be found in child's oral cavity and laser dentistry can be used by dental clinicians to treat these kinds of oral lesions and should be considered as an alternative to conventional surgery Daha fazlası Daha az

Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma

Kandemir N.O. | Barut F. | Gün B.D. | Tekin N.S. | Keser S.H. | Özdamar T.O.

Makale | 2012 | Diagnostic Pathology7 ( 1 ) , pp.279 - 281

Background: In this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized.Methods: A total of 178 biopsy materials of 75 cases diagnosed as classic-type cutaneous Kaposi sarcoma were reviewed. Twenty-five cases showing vesiculobullous features were included in the study. Tumor, epidermis, dermis, and clinical data regarding these cases was evaluated.Results: Vesicular changes were observed in 21 (12%) out of 178 lesions of the 75 cases, while bullous changes were present in only 4 (2%). In all cases where vesi . . .cular and bullous changes were detected, tumor, epidermis, and dermis changes were similar. All cases were nodular stage KS lesions, whereas hyperkeratosis and serum exudation in the epidermis, marked edema in the dermis, and enlarged lymphatic vessels and chronic inflammatory response were observed.Conclusions: Our findings suggest that changes in vascular resistance occurring during tumor progression are the most important factors comprising vesiculobullous morphology.Virtual slides: The virtual slide(s) for this article can be found here: © 2012 Kandemir et al.; licensee BioMed Central Ltd Daha fazlası Daha az

Cardioprotective effect of zileuton: A 5-lipoxygenase inhibitor against myocardial ischemia/reperfusion injury

Gonca E. | Barut F. | Erdem S.

Makale | 2017 | Turkish Journal of Thoracic and Cardiovascular Surgery25 ( 2 ) , pp.273 - 281

Background: This study aims to evaluate the effects of zileuton on myocardial ischemia/reperfusion injury and ischemia-induced ventricular arrhythmias and to investigate the role of 5-lipoxygenase pathway in the pathogenesis of myocardial ischemia/reperfusion injury. Methods: In anesthetized rats, myocardial ischemia was induced by the ligation of the left main coronary artery for 30 min before 120-min reperfusion period. Zileuton was given both at the doses of 3 and 10 mg/kg 15 min before the ligation. During the experiment, electrocardiography, blood pressure, and heart rate were recorded. The duration of arrhythmia types were det . . .ermined during the ischemic period. To evaluate the ischemia/reperfusion injury in the myocardial tissue, histopathological examination was performed and the infarct size was determined by 2,3,5-triphenyltetrazolium chloride staining. Results: Zileuton at a dose of 3 mg/kg significantly decreased the infarct size and the tissue injury score obtained using histopathological examinations (infarct size [% of the area at risk]: zileuton 3 mg/kg 36±7% versus control 66±6%, p < 0.05). Zileuton 10 mg/kg was found to be ineffective. Both 3 and 10 mg/kg doses of zileuton did not shorten the duration of arrhythmias during the ischemic period. Conclusion: Our study results showed that 3 mg/kg dose of zileuton protected the heart against myocardial ischemia/ reperfusion injury. However, it was ineffective to reduce the ischemia-induced ventricular arrhythmias. Based on these results, zileuton may be a promising drug for the treatment of myocardial ischemia/reperfusion injury. © 2017. Turkish Society of Cardiovascular Surgery Daha fazlası Daha az

Renal cell carcinoma presenting with cutaneous metastasis: A case report

Kandemir N.O. | Barut F. | Yilmaz K. | Tokgoz H. | Hosnuter M. | Ozdamar S.O.

Makale | 2010 | Case Reports in Medicine2010 , pp.273 - 281

Renal cell carcinoma is the most common kidney tumor in adults. Cutaneous metastasis is a rare first symptom of the disease. This paper describes the diagnosis of a renal cell carcinoma that was indicated by cutaneous metastasis in the head and neck region, and considers the etiopathogenesis of such cases. A careful skin examination is important to detect cutaneous metastasis associated with renal cell carcinomas. Metastatic skin lesions in the head and neck region must be taken into consideration during a differential diagnosis. Copyright © 2010 Nilufer Onak Kandemir et al.

Reproducibility of fuhrman nuclear grading of renal cell carcinoma: A preliminary study

Bektaş S. | Barut F. | Bahadir B. | Dogan G.Ü.N.B. | Kandemir N.O. | Karadayi N. | Özdamar Ş.O.

Makale | 2009 | Turkish Journal of Medical Sciences39 ( 2 ) , pp.185 - 189

Background: The aim of this study was to evaluate intraobserver and interobserver reproducibility of Fuhrman nuclear grading of renal cell carcinoma. Methods: Pathology slides from 46 cases of renal cell carcinoma were rescored by 2 pathologists according to the Fuhrman system. Both intraobserver and interobserver reproducibility were assessed using kappa statistics. Results: The initial Fuhrman grade was grade 1 in 4 of the cases (8.7%), grade 2 in 30 (65.2%), grade 3 in 11 (23.9%), and grade 4 in 1 (2.2%). After reviewing the slides by the same pathologist, grades were reassigned as follows: grade 1 in 8 cases (17.4%), grade 2 in . . .23 (50%), grade 3 in 14 (30.4%), and grade 4 in 1 (2.2%). Intraobserver reproducibility of the Fuhrman system was substantial (k = 0.66). Fuhrman grading by the second pathologist was grade 1 in 11 cases (23.9%), grade 2 in 27 (58.7%), grade 3 in 7 (15.2%), and grade 4 in 1 (2.2%). Interobserver reproducibility of the Fuhrman system was moderate (k = 0.42). Conclusions: Despite substantial intraobserver reproducibility of Fuhrman grading, moderate interobserver reproducibility and low agreement for grade 3 should be a consideration Daha fazlası Daha az

Classic Kaposi’s sarcoma showing multiple organ involvement: A case report and brief review of literature

Onak Kandemir N. | Barut F. | Yurdakan G. | Doğan Gün B. | Birol İ.E. | Özdamar Ş.O.

Makale | 2017 | Turk Onkoloji Dergisi32 ( 4 ) , pp.165 - 168

Kaposi’s sarcoma (KS) is a vascular tumor with different epidemiological, clinical, and morphologic features, and KS-associated herpes virus plays role in its etiology. In the pathogenesis of these tumors, inflammatory, immunological, and oncogenic factors are closely related to each other. Classic KS is characterized by cutaneous lesions and mild clinical course. However, with the addition of various factors to the disease process, KS lesions can occur in unusual locations and cause unexpected clinical symptoms. In this study, we present a case of gastrointestinal system involvement in KS and lymphadenopathic KS following interstit . . .ial lung disease and steroid treatment in a 72-year-old male patient who was treated for cutaneous classic KS for 10 years. Histopathologic differential diagnosis of KS lesions seen in unusual localizations is discussed in the context of literature. © 2017, Turkish Society for Radiation Oncology Daha fazlası Daha az

The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules

Altas A. | Kuzu F. | Arpaci D. | Unal M. | Can M. | Barut F. | Kokturk F.

Makale | 2017 | International Journal of Endocrinology2017 , pp.165 - 168

Aim. Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases. Materials and Methods. In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules. After performing FNAB, IGF-1 and IGFBP-3 . . . levels were determined in blood and aspiration samples. Results. The serum levels of IGF-1 (232.8 ± 12.9 ng/ml) and IGFBP-3 (4.8 µg/ml) were found significantly higher than that of the intranodular IGF-1 (39.1 ng/ml) and intranodular IGFBP-3 levels (0.173 µg/ml) ( Daha fazlası Daha az

Recurrent partial hydatidiform mole

Barut A. | Arikan I. | Harma M. | Harma M.I. | Barut F. | Coskan A.

Makale | 2011 | Journal of the Pakistan Medical Association61 ( 10 ) , pp.1016 - 1017

Hydatidiform moles are abnormal conceptions characterised by atypical hyperplastic trophoblasts and hydropic villi. Their incidence is approximately 1 in 1000 pregnancies. The recurrence risk of hydatidiform mole is approximately 1 in 60 in a subsequent pregnancy and 1 in 6.5 in the third pregnancy. In cases with recurrence, the majority of moles are of the same type as that in the preceding pregnancy. Here, we describe the case of a recurrent partial hydatidiform mole after an initial healthy pregnancy. Both pregnancies were evacuated by suction curettage, and the patient was followed by serial monitoring of ß-human chorionic gonad . . .otropin levels. Recurrent molar pregnancy is not an indication for chemotherapy, and subsequent pregnancies do not have an increased risk for other obstetric complications Daha fazlası Daha az

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