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Primary intestinal diffuse large B-cell lymphoma forming multiple lymphomatous polyposis

Barut, Figen | Kandemir, Onak Nilüfer | Karakaya, Kemal | Kökten, Neslihan | Özdamar, Şükrü Oğuz

Article | 2011 | Turkish Journal of Gastroenterology22 ( 3 ) , pp.324 - 328

Multifokal ve atlamalı tutulum, primer gastrointestinal lenfomalar için oldukça nadir görülen bir gelişim paternidir. Klinik ve makroskopik özellikleriyle Crohn hastalığını taklit eden kaldırım taşı görünümü ile dikkat çeken bir ince barsağın multifokal diffüz büyük B hücreli lenfoma olgusu, klinik ve patolojik özellikleri ile beraber sunulmuştur. 25 yaşındaki erkek olgunun jejunoileal rezeksiyon materyalinde, arada sağlam görünümde mukoza alanları izlenen, en büyüğü 2,5 cm çapında olan, ülsere, serozayı da infiltre eden polipoid görünümde multipl lezyonlar izlendi. Mikroskopik incelemede, belirgin nükleollü, veziküler nükleuslu, ge . . .niş eozinofilik sitoplazmalı, pleomorfik, atipik karakterde lenfoid hücrelerden oluşmuş tümöral infiltrasyon gözlendi. Bu atipik hücrelerde vimentin, LCA, CD20, CD79a ile B hücre fenotipinde immün reaksiyon izlendi. Olguya, diffüz büyük B hücreli lenfoma tanısı verildi. Crohn hastalığı belirti ve bulguları ile başvuran hastalarda nadir de olsa bu antitenin olabileceği vurgulanmıştır. Multifocal and skip involvement is quite a rare developmental pattern for primary gastrointestinal lymphomas. A 25-year-old male patient with diffuse large B-cell lymphoma of the small intestine, with macroscopic features and clinical aspects imitating Crohn’s disease and attracting attention with cobblestone-like appearance, is presented herein together with the clinical and pathological features. Multiple ulcerated lesions were also observed infiltrating the serosa with polypoid appearance, 2.5 cm in largest diameter, within the resected jejunoileal specimen, which displayed patchy, healthy-appearing mucosal areas. In microscopic examination, a tumoral infiltration was observed comprised of pleomorphic, atypical lymphoid cells with abundant eosinophilic cytoplasm, marked nucleoli and vesicular nuclei. A B-cell phenotype immunoreaction was observed by vimentin, LCA, CD20, and CD79a in those atypical cells. The diagnosis of the case was diffuse large B-cell lymphoma.The possibility of the presence of this disorder, although rare, is emphasized here for patients applying to the hospital with the signs and symptoms of Crohn’s disease Daha fazlası Daha az

Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-gamma Ligand in Chronic Cerebral Hypoperfusion

Sayan-Ozacmak, Hale | Ozacmak, V. Haktan | Barut, Figen | Jakubowska-Dogru, Ewa

Article | 2011 | CURRENT NEUROVASCULAR RESEARCH8 ( 3 ) , pp.190 - 199

Chronic cerebral hypoperfusion can cause learning and memory impairment and neuronal damage resembling the effects observed in vascular dementia. PPAR-gamma agonists were shown to modulate inflammatory response and neuronal death following cerebral ischemia. The present study was designed to evaluate possible neuroprotective effects of rosiglitazone, a PPAR-gamma agonist, in rat model of chronic cerebral hypoperfusion. Cerebral hypoperfusion was induced by permanent bilateral occlusion of the common carotid arteries. Oral administration of rosiglitazone (1.5, 3, and 6 mg/kg/day) or vehicle was carried out for 5 weeks, starting one w . . .eek before the surgery. Cognitive performance was assessed using the Morris water maze. The density of S100B protein-immunoreactive astrocytes and the OX-42-labeled microglial activation were estimated. Synaptogenesis was also evaluated by the measurement of synaptophysin, the pre-synaptic vesicular protein, level via western blotting technique. Cerebral hypoperfusion for 30 days induced a significant cognitive impairment along with hyperactivation of both microglial and astroglial cells, and reduction of synaptophysin level. Rosiglitazone treatment (3 and 6 mg/kg) not only suppressed the activation of astrocytes and microglia markedly but also alleviated the impairment of memory and increased the synaptophysin level. In conclusion, our results suggest that the chronic administration of rosiglitazone significantly prevents chronic cerebral hypoperfusion-induced brain damage, at least, partly through suppressing glial activation and preserving synaptic plasticity. Thus, it appears that rosiglitazone may be a promising pharmacological agent in the development of therapeutic approaches for the prevention or treatment of cerebrovascular diseases Daha fazlası Daha az

Classic Kaposi's Sarcoma Showing Multiple Organ Involvement: A Case Report and Brief Review of Literature

Onak Kandemir, Nilufer | Barut, Figen | Yurdakan, Gamze | Dogan Gun, Banu | Birol, Ismail Eren | Ozdamar, Sukru Oguz

Review | 2017 | TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY32 ( 4 ) , pp.165 - 168

Kaposi's sarcoma (KS) is a vascular tumor with different epidemiological, clinical, and morphologic features, and KS-associated herpes virus plays role in its etiology. In the pathogenesis of these tumors, inflammatory, immunological, and oncogenic factors are closely related to each other. Classic KS is characterized by cutaneous lesions and mild clinical course. However, with the addition of various factors to the disease process, KS lesions can occur in unusual locations and cause unexpected clinical symptoms. In this study, we present a case of gastrointestinal system involvement in KS and lymphadenopathic KS following interstit . . .ial lung disease and steroid treatment in a 72-year-old male patient who was treated for cutaneous classic KS for 10 years. Histopathologic differential diagnosis of KS lesions seen in unusual localizations is discussed in the context of literature Daha fazlası Daha az

Correlation of vascular endothelial growth factor and vascular endothelial growth factor receptor-1 levels in serum and thyroid nodules with histopathological and radiological variables

Haytaoglu, Gurkan | Kuzu, Fatih | Arpaci, Dilek | Altas, Ayfer | Cana, Murat | Barut, Figen | Kokturk, Furuzan

Article | 2019 | JOURNAL OF LABORATORY PHYSICIANS11 ( 1 ) , pp.51 - 57

BACKGROUND/AIM: Vascular endothelial growth factor (VEGF) is a major cytokine in angiogenesis and has a role on aggressivity of various tumors. The expression of VEGF has been shown to increase in differential thyroid cancer. The aim of the study was to evaluate serum and intranodular VEGF (nVEGF) and VEGF receptor-1 (VEGFR-1) levels in patients with thyroid nodules and their relevance to ultrasonographic and pathological results. MATERIALS AND METHODS: A total of eighty patients were included in the study. Thyroid fine-needle aspiration biopsies were performed, and the levels of serum and nVEGF and VEGFR-1 were measured. Any possib . . .le correlations between serum and nVEGF, VEGFR-1, and biochemical/radiological variables were investigated. RESULTS: There were no significant differences between serum VEGF (sVEGF), nVEGF, sVEGFR-1, nVEGFR-1 levels, number of nodules, size of nodules, and benign and malignant ultrasonographic features. sVEGF and nVEGF were higher in malignant or suspicious nodules than that in benign nodules, but did not reach statistical significance (P 0.05). sVEGFR-1 and nVEGFR-1 levels were higher in hyperthyroid patients than that in euthyroid patients (P < 0.05 and P = 0.003, respectively). nVEGFR-1 level was higher in hypothyroid patients than that in euthyroid patients (P = 0.016). sVEGF level was found to be higher in hyperactive nodules than that in others. Both sVEGFR-1 (P = 0.008) and nVEGF levels (P = 0.01) significantly increased with increasing age. nVEGFR-1 decreased with increasing body mass index (BMI) (P = 0.004). CONCLUSIONS: Our study showed the relationships of sVEGF, nVEGF, sVEGFR-1, and nVEGFR-1 levels with age, gender, BMI, and hyperthyroidism. To determine the role of VEGF/VEGFR-1 in thyroid nodules, further studies are required with a large number of patients Daha fazlası Daha az

Tiroid Karsinomu Olgularında İnce İğne Aspirasyonu Bulguları

Udul, Perihan | Barut, Figen | Özdamar, Şükrü Oğuz

Article | 2018 | Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi25 ( 3 ) , pp.265 - 274

Amaç: Preoperatif dönemde ince iğne aspirasyon sitolojisi uygulanmış 93 tiroid karsinom olgusuna ait sitopatoloji preparatlarının Bethesda Sistemine göre yeniden değerlendirilmesi ve bulguların klinikopatolojik veriler ile olan ilişkisi incelendi. Gereç ve Yöntem: 93 olgunun sitopatoloji raporlarındaki tanılar gözlemci tarafından Bethesda Sistemi’ne göre kategorize edildi (grup 1) ve önceki tanıları bilinmeksizin sitopatoloji preparatları yeniden tarandı; Bethesda Sistemi’ne göre tanı verildi (grup 2). Her iki tanı grubu arasındaki fark ve/veya uyumsuzluk sorgulandı. Folliküler patern gösteren karsinomların sitopatoloji tanıları ara . . .sındaki fark ve/ veya uyumsuzluk da araştırıldı. Yaş, cinsiyet, tümör tipi, tümörün boyutu, tümör odak sayısı, karsinoma eşlik eden komponent ve ilk rezeksiyon tipi olarak değerlendirme kapsamına alınan klinikopatolojik veriler incelendi. Bulgular: Çalışmamızda iki tanı grubu arasındaki fark (p=0.522) anlamlı bulunmazken, gruplar arasında orta derecede uyum saptandı (kappa=0.493). Folliküler patern gösteren karsinom olgularında ise iki grup arasındaki fark istatistiksel olarak anlamlı bulunmazken (p=0.560); orta derecede uyum gözlendi (kappa=0.555). Her iki tanı grubunun tümör tipi, tümör odak sayısı ve eşlik eden komponent ile olan ilişkileri istatistiksel olarak anlamlı bulunmazken, grup 1’in tümör boyutu ile ilişkisi anlamlı bulundu. Sonuçlar: Çalışmamızdaki olguların tamamı histopatolojik olarak karsinom tanısı almış ise de sitopatolojik olarak hepsi ‘Malign’ grupta kategorize edilememiştir. Bethesda Sistemi’ne göre her tanı kategorisinde az da olsa malignite riski olduğundan ince iğne aspirasyon sitolojisine ek olarak klinik ve radyolojik özelliklerin dikkatli olarak değerlendirilmesi tiroid karsinomu olgularının gözden kaçırılmamasını sağlayacaktır Objective: The re-evaluation of 93 cytopathology preparations belonging to thyroid carcinoma cases that underwent fine needle aspiration cytology in the preoperative period according to the Bethesda System and the examination of the relationship between findings and clinicopathological data. Material and Method: Cytopathology reports in 93 cases were categorized by observers that have been diagnosed according to the Bethesda System (group 1) and cytopathology preparations were scanned again without knowing the previous diagnosis; was diagnosed according to the Bethesda System (group 2). The difference and/or non- compliance between the two diagnostic groups have been questioned. The difference and/or non-compliance between carcinomas showing follicular patterns through cytopathology diagnosis were also investigated. Clinicopathological data which included the first resection as age, gender, tumor type, tumor size, number of tumor foci, concomitant carcinoma component and the type of evaluation were analyzed. Results: In our study, the difference between the two diagnostic groups was not significant (p=0.522) but compliance between the groups was moderate (kappa=0.493). There was no statistically significant difference between the two groups showing the pattern of follicular carcinomas (p=0.560); compliance was observed moderate (kappa= 0.555). There was no statistically significant relationship between each of the two diagnostic groups, tumor type, number of tumor foci and accompanying components; on the other hand, the corrrelation between tumor size and group 1 was significant. Conclusion: Even all the patients in our study have a diagnosis of carcinoma histopathologically; cytologically they could not be categorized as ‘malignant’. According to the Bethesda System, in each diagnostic category there is a slight risk of malignancy and in addition to the fine needle aspiration cytology, a careful evaluation of clinical and radiological features will ensure the situation of patients with thyroid carcinoma not being overlooked Daha fazlası Daha az

Oxidized low-density lipoproteins accumulate in rat lung after experimental lung edema induced by alpha-naphthylthiourea (ANTU)

Sipahi, EY | Tekin, IO | Comert, M | Barut, Figen | Ustun, H | Sipahi, TH

Article | 2004 | PHARMACOLOGICAL RESEARCH50 ( 6 ) , pp.585 - 591

Oxidation of the low-density lipoprotein (LDL) results in the production of modified LDLs. Oxidation of LDL cholesterol plays a role on the pathogenesis of endothelial dysfunction. This study was designed to investigate the possible participation of the oxidative modification of low density lipoprotein in the lung edema induced by alpha-naphthylthiourea (ANTU), which is a well-known noxious chemical agent on the lung endothelium. When ANTU injected intraperitoneally into rats (15 mg kg(-1)), it produced lung edema as indicated by an increase in lung weight/body weight (LW/BW) ratio and pleural effusion (PE) reaching a maximum within . . . 4 h. A significant lung edema was observed 4 h after intraperitoneally injection of alpha-naphthylthiourea when compared with olive oil-injected control rats. On microscopic examination of alpha-naphthylthiourea-treated rats were shown to have severe lung injury, while no change was observed in olive oil-treated control rats. While there were no staining in control lungs, positive oxidized low-density lipoproteins immune-fluorescent staining were observed in lung edema group. Our study showed that oxidized low-density lipoprotein (oxLDL) accumulated in ANTU-induced lung damage. This is the first study in which accumulation of oxLDL molecules in the intact lung tissue were shown by fluorescent immune-staining method in experimental lung edema. The potential role of oxLDL in this pathology are still under investigation. (C) 2004 Elsevier Ltd. All rights reserved Daha fazlası Daha az

Agmatine attenuates intestinal ischemia and reperfusion injury by reducing oxidative stress and inflammatory reaction in rats

Turan, İnci | Özaçmak-Sayan, Hale | Özaçmak, Veysel Haktan | Barut, Figen | Araslı, Mehmet

Article | 2017 | Life Sciences189 , pp.23 - 28

Aims Oxidative stress and inflammatory response are major factors causing several tissue injuries in intestinal ischemia and reperfusion (I/R). Agmatine has been reported to attenuate I/R injury of various organs. The present study aims to analyze the possible protective effects of agmatine on intestinal I/R injury in rats. Main methods Four groups were designed: sham control, agmatine-treated control, I/R control, and agmatine-treated I/R groups. IR injury of small intestine was induced by the occlusion of the superior mesenteric artery for half an hour to be followed by a 3-hour-long reperfusion. Agmatine (10 mg/kg) was administer . . .ed intraperitoneally before reperfusion period. After 180 min of reperfusion period, the contractile responses to both carbachol and potassium chloride (KCl) were subsequently examined in an isolated-organ bath. Malondialdehyde (MDA), reduced glutathione (GSH), and the activity of myeloperoxidase (MPO) were measured in intestinal tissue. Plasma cytokine levels were determined. The expression of the intestinal inducible nitric oxide synthase (iNOS) was also assessed by immunohistochemistry. Key findings The treatment with agmatine appeared to be significantly effective in reducing the MDA content and MPO activity besides restoring the content of GSH. The treatment also attenuated the histological injury. The increases in the I/R induced expressions of iNOS, IFN-?, and IL-1? were brought back to the sham control levels by the treatment as well. Significance Our findings indicate that the agmatine pretreatment may ameliorate reperfusion induced injury in small intestine mainly due to reducing inflammatory response and oxidative stress. © 2017 Elsevier Inc Daha fazlası Daha az

Rosiglitazone treatment reduces hippocampal neuronal damage possibly through alleviating oxidative stress in chronic cerebral hypoperfusion

Özaçmak-Sayan, Hale | Özaçmak, Veysel Haktan | Barut, Figen | Jakubowska-Doğru, Ewa

Article | 2012 | Neurochemistry International61 ( 3 ) , pp.287 - 290

Oxygen free radicals and lipid peroxidation may play significant roles in the progress of injury induced by chronic cerebral hypoperfusion of the central nervous system. Rosiglitazone, a well known activator of PPAR?, has neuroprotective properties in various animal models of acute central nervous system damage. In the present study, we evaluate the possible impact of rosiglitazone on chronic cerebral hypoperfused-rats in regard to the levels of oxidative stress, reduced glutathione, and hippocampal neuronal damage. Chronic cerebral hypoperfusion was generated by permanent ligation of both common carotid arteries of Wistar rats for . . .one month. Animals in treatment group were given rosiglitazone orally at doses of 1.5, 3, or 6 mg/kg per day of the 1 month duration. The treatment significantly lowered the levels of both malondialdehyde and neuronal damage, while elevated the reduced glutathione level markedly. These findings suggest that the beneficial effect of rosiglitazone on hypoperfusion-induced hippocampal neuronal damage might be the result of inhibition of oxidative insult. © 2012 Elsevier Ltd. All rights reserved Daha fazlası Daha az

Chronic treatment with resveratrol, a natural polyphenol found in grapes, alleviates oxidative stress and apoptotic cell death in ovariectomized female rats subjected to chronic cerebral hypoperfusion

Özaçmak, Veysel Haktan | Özaçmak-Sayan, Hale | Barut, Figen

Article | 2016 | Nutritional Neuroscience19 ( 4 ) , pp.176 - 186

Objectives: Resveratrol appears to have neuroprotective potential in various animal models of brain disorders including cerebral ischemia and neurodegenerative diseases. Chronic cerebral hypoperfusion is a well-known pathological condition contributing to the neurodegenerative diseases such as vascular dementia. Purpose of the present study is to evaluate the possible therapeutic potential of resveratrol in a model of vascular dementia of ovariectomized female rats. Assessment of the potential was based on the determination of brain oxidative status, caspase-3 level, glial fibrillary acidic protein (GFAP), and neuronal damage on hip . . .pocampus and cerebral cortex. Methods: For creating the model of chronic cerebral hypoperfusion, ovariectomized female Wistar rats were subjected to the modified two vessel occlusion method, with the right common carotid artery being occluded first and the left one a week later. Results: At the 15th day following the ligation, neuronal damage was accompanied by the increased immunoreactivities of both GFAP and caspase-3, and significant neurodegeneration was evident in the hippocampus and cortex, all of which were significantly alleviated with resveratrol treatment (10 mg/kg). Biochemical analysis revealed that the resveratrol treatment decreased lipid peroxidation and restored reduced glutathione level as well. Discussion: The collected data of the present study suggest that the administration of resveratrol may provide a remarkable therapeutic benefit for vascular dementia, which is most likely related to the prevention of both apoptotic cell death and oxidative stress. We believe that therapeutic efficacy of resveratrol deserves to be tested for potential clinical application in postmenopausal elderly women suffering from vascular dementia. © 2015 W. S. Maney & Son Ltd 2015 Daha fazlası Daha az

Obstructive jaundice leads to accumulation of oxidized low density lipoprotein in human liver tissue

Comert, Mustafa | Ustundag, Yucel | Tekin, Ishak Ozel | Gun, Banu Dogan | Barut, Figen

Letter | 2006 | WORLD JOURNAL OF GASTROENTEROLOGY12 ( 31 ) , pp.5094 - 5095

Oxidized low density lipoprotein (ox-LDL) molecule is one of the most important modified lipoproteins produced during the oxidative stress. Modified lipoproteins have been defined as being part of the immune inflammatory mechanisms in association with oxidant stress. We have reported the accumulation of ox-LDL in Balb/c mice liver after bile duct ligation previously. Here, we investigated this finding in human beings with obstructive jaundice. Our study demonstrates that obstructive jaundice results in tremendous accumulation of ox-LDL in the liver tissue of patients. (C) 2006 The WJG Press. All rights reserved.

The Effects of Epilepsy on Ischemia-induced Ventricular Arrhytmias And Myocardial Injury in Anesthetized Rats

Gonca, Ersoz | Basoglu, Gulselin | Barut, Figen | Sahin, Deniz

Conference Object | 2017 | ACTA PHYSIOLOGICA221 , pp.63 - 63

WOS: 000419806200105

Histological subgroups in classic kaposi sarcoma: A preliminary study

Kandemir, Nilüfer Onak | Gün, Banu Doğan | Barut, Figen | Yurdakan, Gamze | Bahadır, Burak | Bektaş, Sibel | Gün, Mustafa | Keser, Sevinç Hallaç | Özdemir, Nagehan | Özdamar, Şükrü Oğuz

Article | 2010 | TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY44 ( 2 ) , pp.73 - 78

Background and Design: Kaposi sarcomas (KS) are vascular tumors with a low malignant potential which include overlapping infectious, immunologic, and neoplastic processes. Recently, many histological subtypes have been defined. Material and Method: In the present study, 151 cutaneous classic KS lesions in 56 patients were retrospectively evaluated with regard to histological subtypes. Determination of the subtypes was based on the predominant histopathological component in the lesion. We examined changes in epidermis and dermis along with intratumoral inflammatory response characteristics in the lesions. By defining histopathologica . . .l variants of the cases, differences regarding subtypes were investigated. Results: Cases that bear the ordinary characteristics of KS and those that can not be classified otherwise, comprised 82..8% of the study group. Twenty-six cases showed consistency with the subtypes outlined in the literature in terms of their histopathological properties. The most common histological subtype was the lymphangiectatic variant in 7.3% of the cases. Bullous (2.6%), lymphangioma like (2.6%), intravascular (2%), and pyogenic granuloma like (2%) variants were less common. The most uncommon histological subtype was micronodular (0.6%) type. Lymphangiectatic, bullous, intravascular, and pyogenic granuloma like variants were frequently observed in the nodular stage of KSs. Lympangioma like changes were seen to be present in the early KS lesions. Lymphangiectatic type was oftenly associated with bullous component, whereas pyogenic granuloma like type demonstrated superficial ulceration and intense inflammatory response. Lymphangioma like and intravascular types exhibited a characteristic appearance, while other variants were accompanied by components belonging to different subtypes. Conclusion: In KS, histopathological subtypes can develop as a result of different pathological processes. The next stage of the current study, which is one of the largest case series in the literature, will be investigation of the clinical and prognostic characteristics of the variants. (Turkderm 2010; 44: 73-8 Daha fazlası Daha az

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