Ermis B. | Aydemir C. | Taspinar O. | Cagavi F. | Bahadir B. | Ozdemir H.

Makale | 2006 | Archives of Disease in Childhood: Fetal and Neonatal Edition91 ( 5 )

[No abstract available]

Gun B.D. | Ozdamar S.O. | Bahadir B. | Uzun L.

Makale | 2009 | Ear, Nose and Throat Journal88 ( 7 ) , pp.1005 - 1009

Salivary gland tumors that display myoepithelial differentiation exclusively or predominantly are relatively uncommon, and the assessment of malignancy in a myoepithelial tumor can be difficult. We report a case of parotid gland myoepithelioma composed predominantly of spindle cells with focal capsular invasion. The patient was a 65-year-old woman who presented with a painless mass in the right preauricular region. Histologically, the tumor had a solid and multinodular growth pattern and was predominantly made up of spindle cells with a minor component of epithelioid cells with moderate cellular atypia. Focal regions of tumor cells . . .infiltrated the capsule with tongue-like processes, but tumor infiltration into the adjacent parotid tissue was absent. The tumor cells showed strong cytoplasmic immunoexpression of vimentin, pankeratin, S-100 protein, and smooth-muscle actin. Immunostains with glial fibrillary acidic protein, melanoma marker, epithelial membrane antigen, and carcinoembryonic antigen were negative. Expression of p53 was observed focally in the nuclei of the tumor cells. A final diagnosis of salivary gland myoepithelioma with focal capsular invasion was made, and the case was regarded as a myoepithelial tumor of uncertain malignant potential. In this report, we discuss the histologic criteria required to diagnose malignancy in salivary gland myoepithelial tumors Daha fazlası Daha az

Yurdakan G.N. | Gün B.D. | Bahadir B. | Sönmez A. | Açikgöz B. | Kalayci M. | Özdamar Ş.O.

Makale | 2008 | Ondokuz Mayis Universitesi Tip Dergisi25 ( 2 ) , pp.67 - 71

Choroid plexus carcinoma which is a rare malign tumor of central nervous system. These tumors constitue 20-30% of the primary choroid plexus tumors and are more frequently situate in the lateral ventricle. Choroid plexus carcinoma is invasive and involves areas of necrosis and hemorrhage. Our case is a 4 year old girl who was admitted to university hospital presented with headache, stupor and lethargy. In cranial computerized tomography, a tumor was detected in right temporoparietal lob. Histopathologically the tumor cells were composed of branching papillary structures surrounding a fibrovascular core and infiltrate in brain parenc . . .hyma. Large areas of necrosis were detected within the tumor. High mitotic activity was also present. Tumor were not showed to react with mucicarmen, but diffuse reaction for S-100 and focal positive reaction for GFAP, pankeratin(Clone AE1/AE3) and CK7 were observed. Finally, the tumor was diagnosed as choroid plexus carcinoma. This case is presented here, because of its rarity and importance in differential diagnosis of papillary tumors of central nervous system Daha fazlası Daha az

Behzatoglu K. | Bahadir B. | Huq G.E. | Kaplan H.H.

Gözden Geçirme | 2005 | Diagnostic Cytopathology32 ( 6 ) , pp.367 - 369

Although infarction of parotid gland pleomorphic adenoma (PA) following fine-needle aspiration (FNA) has been well-documented, spontaneous infarction of PA has remained as an uncommon entity in the literature. To our knowledge, we report the second case of spontaneous infarction occurring in a parotid gland PA. A 44-yr-old man presented with a 2-yr history of slowly enlarging right parotid mass, which had become painful 1 mo before performing FNA biopsy. Smears revealed abundant necrotic debris, atypical squamous cells, and small cells with dark nuclei suggestive of a carcinoma. Histologic examination of the tissue fragments demonst . . .rated degenerated clusters of cells and chondromyxoid matrix. The parotidectomy specimen had features consistent with those of an infarcted PA. Although appears to be rare, spontaneous infarction of PA should be considered in the differential diagnosis, since necrosis may mimic carcinoma and cause misinterpretation of necrosis as an indication of malignancy, in an otherwise benign salivary gland neoplasm. © 2005 Wiley-Liss, Inc Daha fazlası Daha az

Gün B.D. | Özdamar Ş.O. | Çolak S. | Bahadir B. | Kuzey G.M.

Makale | 2006 | Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi52 ( 4 ) , pp.185 - 187

Gout is a metabolic disorder in which there is either an increase in production or a decrease in excretion of uric acid leading to hyperuricemia. Hyperuricemia results in the deposition of monosodium urate crystals in joints and visceral organs and continued deposition eventually results in chronic tophaceous gout. We report a case of gouty tophi in a 45-year-old man who developed nodules on both lateral aspects of the malleoli with a history of arthropathy. In laboratory investigation, blood chemistry showed marked hyperuricemia (8.40 mg/dl). Macroscopically, the lesions were circumscribed whitish-gray masses. Histologically, both . . .lesions contained areas of amorphous brown crystal deposits and they were surrounded by a foreign body type granulomatous infiltrate. The crystals revealed specific birefringence, a diagnostic characteristic of the monosodium urate crystals, with a polarizing filter. Gout deposits in skin (tophi) are uncommon. The aim of this report is to emphasize the importance of considering this disease entity in the differential diagnosis of a soft tissue lesion in a patient with chronic arthritis Daha fazlası Daha az

Behzatoglu K. | Canberk Ş. | Bahadir B. | Öznur M.

Mektup | 2007 | Pathology International57 ( 3 ) , pp.167 - 170

[No abstract available]

Behzatoglu K. | Bahadir B.

Makale | 2007 | Pathology International57 ( 2 ) , pp.115 - 119

Malignant granular cell tumor, although uncommon, should be differentiated from a number of granular cell-containing tumors. Reported herein is a distinctive variant of malignant granular cell tumor, clinically presenting as a rapidly enlarging scrotal mass, in which some areas morphologically displayed features indistinguishable from Kaposi sarcoma. Cells in areas simulating Kaposi sarcoma were immunohistochemically the same as typical granular cells in other portions of the tumor. The recognition of this pattern is important because it may predominate and overshadow the original nature of tumor. © 2007 The Authors.

Gun B.D. | Bahadir B. | Behzatoglu K. | Gun M.O. | Ozdamar S.O.

Makale | 2007 | APMIS115 ( 2 ) , pp.115 - 119

Elastofibroma is a rare fibrous lesion characterized by accumulated abnormal elastic fibers whose etiology remains largely unknown. In this study, we analyzed seven cases of elastofibroma to further explore the characteristics of its cellular composition. Immunohistochemistry was performed for mast cell tryptase, S-100 protein, vimentin, CD34, smooth muscle actin, desmin and collagen type IV. Histochemical staining methods for Gomori's trichrome and Verhoeff elastica-van Gieson were also evaluated. Histopathologically, a haphazard array of collagen, eosinophilic amorphous fibers, and globules in a fibrous tissue was seen. The elasti . . .c nature of the fibers was confirmed by elastic stain, and with Gomori's trichrome collagen fibers were also demonstrated. The interspersed spindle or stellate cells were almost consistently positive for vimentin and frequently positive for CD34. Mast cell tryptase-positive cells were present in five of the cases. Collagen type IV immunoreactivity was seen in two cases. No staining was observed with smooth muscle actin, desmin or S-100 protein. Our findings suggest that CD34-positive mesenchymal cells are an integral component of elastofibroma. © 2007 The Authors Daha fazlası Daha az

Gul S. | Bahadir B. | Kalayci M. | Acikgoz B.

Makale | 2010 | Pediatric Neurosurgery45 ( 6 ) , pp.410 - 413

Noncommunicating spinal intradural extramedullary arachnoid cysts are an extremely rare cause of spinal cord compression. An 8-year-old boy presented with progressive paraparesis. Magnetic resonance imaging revealed a posterior intradural extramedullary arachnoid cyst extending from T11 to L 3 vertebral bodies. The multilevel noncommunicating cyst was totally removed by simple delivery without rupture through a single-level laminoplasty. To our knowledge, no such case has been reported in the literature. Copyright © 2009 S. Karger AG, Basel.

Kuzu F. | Arpaci D. | Cakmak G.K. | Emre A.U. | Elri T. | Ilikhan S.U. | Bahadir B.

Makale | 2016 | Annals of Medicine and Surgery6 , pp.64 - 67

Background: The accurate identification of hyperfunctioning parathyroid (HP) gland is the only issue for definitive surgical treatment in primary hyperparathyroidism (pHPT). Various imaging and operative techniques have been proposed to confirm the localization of the diseased gland. Nevertheless, none of these methods proved to be the gold standard. The presented study aimed to assess the value of parathyroid hormone assay in preoperative ultrasound guided fine needle aspiration (FNA)-PTH washout fluid to verify the correct localisation for focused parathyroidectomy without intra-operative PTH monitoring. Material and Methods: The . . .retrospective analysis of 57 patients with pHPT who underwent FNA-PTH was conducted from a prospective database. Biochemical assessment together with radiological (ultrasonography) and nuclear (MIBI scan) imaging was reviewed. Associations between FNA-PTH washout values and localization technics were evaluated and compared in terms of operative findings. Results: Focused parathyroidectomy without intraoperative PTH monitoring was performed to 45 patients with high FNA-PTH values. The median largest diameter of the target parathyroid lesion identified by ultrasonography was 13 mm (range, 6 to 36). The median serum PTH level was 190 pg/mL (range, 78 to 1709; reference range, 15 to 65) whereas the median washout PTH was 2500 pg/mL (range, 480 to 3389). According to operative findings high FNA-PTH levels correctly identified parathyroid adenoma in 40 cases (89% of sensitivity and 100% of specificity and positive predictive value) whereas MIBI scan localized the lesion in 36 of these cases (80% of sensitivity). Conclusions: The higher level of PTH in preoperative ultrasound guided FNA washout is a considerable data to predict the correct localization of HP, particularly in circumstances of greater values than the serum PTH level. However, although its specificity is high, in cases of coexisting nodular thyroid disease, associated additional HP might be missed at focused parathyroidectomy without PTH monitoring, leading to recurrent disease. © 2016 Daha fazlası Daha az

Gokce M. | Saydam O. | Hanci V. | Can M. | Bahadir B.

Makale | 2012 | Journal of Cardiothoracic Surgery7 ( 1 ) , pp.64 - 67

Background: The goal of our study is to evaluate the effects of antioxidant vitamins (vitamin C and E), Coenzyme Q10 (CoQ10) and dexamethasone (Dxm) in experimental rat models with pulmonary contusion (PC).Methods: Rats were randomly divided into six groups. Except for the control, all subgroups had a moderate pulmonary contusion. Animals in the group I and group II received intraperitoneal saline, group III received 10mg.kg-1 CoQ10 group IV received 100mg.kg-1 vitamin C, group V received 150mg.kg-1 vitamin E, and group VI received 10mg.kg-1 Dxm. Blood gas analysis, serum nitric oxide (NO) and malondialdehyde (MDA) levels as well as . . . superoxide dismutase (SOD) activity assays, bronchoalveolar lavage (BAL) fluid and histopathological examination were performed.Results: Administration of CoQ10 resulted in a significant increase in PaO2 values compared with the group I (p = 0.004). Levels of plasma MDA in group II were significantly higher than those in the group I (p = 0.01). Early administration of vitamin C, CoQ10, and Dxm significantly decreased the levels of MDA (p = 0.01). Lung contusion due to blunt trauma significantly decreased SOD activities in rat lung tissue compared with group I (p = 0.01). SOD levels were significantly elevated in animals treated with CoQ10, Vitamin E, or Dxm compared with group II (p = 0.01).Conclusions: In our study, CoQ10, vitamin C, vitamin E and Dxm had a protective effect on the biochemical and histopathological outcome of PC after experimental blunt thorax trauma. © 2012 Gokce et al.; licensee BioMed Central Ltd Daha fazlası Daha az

Ayoglu H. | Gul S. | Hanci V. | Bahadir B. | Bektas S. | Mungan A.G. | Turan I.O.

Makale | 2010 | Journal of Clinical Neuroscience17 ( 6 ) , pp.770 - 773

We investigated the effect of two different doses of dexmedetomidine on vasospasm in a rat model of subarachnoid haemorrhage (SAH). SAH was induced by injecting 0.3 mL blood into the cisterna magna in all rat groups except the control (Group C). At 1 hour and 24 hours after SAH, 5 µg/kg dexmedetomidine was given to group D5, and 10 µg/kg dexmedetomidine was given to group D10. No medication was administered to the haemorrhage group (Group H). Malondialdehyde (MDA) and paraoxonase (PON) levels were measured at 48 hours after SAH. Mean wall thickness (MWT), mean luminal diameter (MLD), and proliferating cell nuclear antigen (PCNA) exp . . .ression of the basilar artery were evaluated. MDA levels and MWT were lower in the dexmedetomidine groups. The lowest MDA levels and MWT were found in Group D10. The MLD was lowest in Group H. PCNA expression was observed only in Group D10. We concluded that dexmedetomidine reduces oxidative stress and vasospasm following SAH in a dose-dependent manner. © 2009 Elsevier Ltd. All rights reserved Daha fazlası Daha az