Filtreler

Bulunan: 54 Adet 0.093 sn

Konu Başlıkları : Oxidative stress ✕

Koleksiyon [23]

İlgili Araştırmacılar [30]

Ambargo Durumu [1]

Tam Metin [2]

Yazar [90]

Yayın Türü [3]

Yayın Yılı [17]

Yayın Dili [2]

Dergi Adı [48]

Yayıncı [22]

Konu Başlıkları [90]

Tez Danışmanı [1]

Protection by L-carnitine against radiation-induced ileal mucosal injury in the rat: Pattern of oxidative stress, apoptosis and cytokines

Akpolat M. | Gulle K. | Topcu-Tarladacalisir Y. | Safi Oz Z. | Bakkal, Bekir Hakan | Arasli M. | Ozel Turkcu U.

Purpose: In this study, we tested the effects of L-carnitine (LC) on radiation-induced ileal mucosal damage. Materials and methods: Thirty Wistar albino rats were divided into five groups. The control group received physiological saline intraperitoneally (i.p.). Radiation-1 and radiation-2 groups received whole-body X-irradiation of 8.3 Gy as a single dose. These groups were sacrificed at the 6th hour and 4th day after irradiation, respectively. The Radiation-1 + LC and the radiation-2 + LC groups received the same dose irradiation plus a daily dose of 200 mg/kg LC. LC was applied one day befo ...Daha fazlası

Makale 2013 International Journal of Radiation Biology89 ( 9 ) , pp. 7 - 740 783 Görüntülenme

Erişime Açık

The effect of erythropoietin on anastomotic healing of irradiated rats

Turkcu U.O. | Cakmak G.K. | Demir E.O. | Bakkal, Bekir Hakan | Oner M.O. | Okyay R.D. | Bassorgun I.C.

Aim: The aim of the present study is to evaluate the possible protective effects of erythropoietin (EPO) on anastomotic wound healing after preoperative radiotherapy according to its pleiotropic mechanism of action. Methods: Thirty-two male Wistar albino rats were randomized into four groups containing eight rats each: ANAS group, standard resection plus anastomosis; RT+ANAS group, radiation plus standard resection plus anastomosis; ANAS+EPO group, standard resection plus anastomosis plus EPO; RT+ANAS+EPO, radiation plus standard resection plus anastomosis plus EPO. All animals were sacrificed ...Daha fazlası

Makale 2012 Journal of Investigative Surgery25 ( 2 ) , pp. 1 - 135 1176 Görüntülenme

Erişime Açık

The influence of dietary alpha-solanine on the waxmoth galleria mellonellal

Büyükgüzel, Ender | Büyükgüzel, Kemal | Erdem, Meltem | Adamski, Zbigniew | Adamski, Zbigniew | Marciniak, Pawel | Ziemnicki, Kazimierz

Plant allelochemicals are nonnutritional chemicals that interfere with the biology of herbivores. We posed the hypothesis that ingestion of a glycoalkaloid allelochemical, ?-solanine, impairs biological parameters of greater wax moths Galleria mellonella. To test this idea, we reared wax moths on artificial diets with 0.015, 0.15, or 1.5 mg/100 g diet of ?-solanine. Addition of ?-solanine to the diet affected survival of seventh-instar larvae, pupae, and adults; and female fecundity and fertility. The diet containing the highest ?-solanine concentration led to decreased survivorship, fecundity ...Daha fazlası

Makale 2013 Archives of Insect Biochemistry and Physiology83 ( 1 ) , pp. 1 - 24 1331 Görüntülenme

Erişime Açık

Effect of boric acid on antioxidant enzyme activity, lipid peroxidation, and ultrastructure of midgut and fat body of Galleria mellonella

Büyükgüzel, Ender | Büyükgüzel, Kemal | Snela, Milena | Erdem, Meltem | Radtke, Katarzyna | Ziemnicki, Kazimierz | Adamski, Zbigniew

Boric acid is widely used as an insecticide, acaricide, herbicide, and fungicide and also during various industrial processings. Hence, numerous populations are subjects to this toxic compound. Its action on animals is still not fully known and understood. We examined the effect of boric acid on larvae of greater wax moth (Galleria mellonella). The chemical appeared to be toxic for larvae, usually in a concentration-dependent manner. Exposed groups revealed increased lipid peroxidation and altered activity of catalase, superoxide dismutase, glutathione S-transferase, and glutathione peroxidase ...Daha fazlası

Makale 2013 Cell Biology and Toxicology29 ( 2 ) , pp. 1 - 129 1096 Görüntülenme

AT1 receptor blocker candesartan-induced attenuation of brain injury of rats subjected to chronic cerebral hypoperfusion

Özaçmak, Veysel Haktan | Sayan, Hale | Çetin, Alpay | Akyıldız-İğdem, Ayşenur

One of common pathophysiological states associated with central nervous system is chronic cerebral hypoperfusion (CH) that frequently occurs in conditions such as vascular dementia and Alzheimer's disease. Long term blockage of angiotensin II type 1 (AT 1 ) receptor provides protection from ischemia induced injury of brain as well as reduction of cerebrovascular inflammation. Examining effect of the blockage on reduced glutathione (GSH), ascorbic acid (AA), and lipid peroxidation were of purpose in the present study. Modeling CH, rats were subjected to permanent occlusion of common carotid art ...Daha fazlası

Makale 2007 Neurochemical Research32 ( 8 ) , pp. 1 - 1321 750 Görüntülenme

Pharmacological preconditioning with erythropoietin reduces ischemia-reperfusion injury in the small intestine of rats

Sayan, Hale | Özaçmak, Veysel Haktan | Şen, Feyza | Çabuk, Mehmet | Atik-Yörük, Duygu | Akyıldız-İğdem, Ayşenur | Özaçmak, I. Diler

Aims: Considering the implications that arose from several recent experimental studies using recombinant human erythropoietin in rodents, erythropoietin has been regarded as a pharmacological preconditioning agent. The purpose of the present study was to evaluate whether erythropoietin has a preconditioning effect against ischemia and reperfusion injury in the small intestine of the rat. Main methods: Intestinal ischemia was induced in male Wistar rats by clamping the superior mesenteric artery for 30 min, followed by reperfusion for 180 min. Recombinant human erythropoietin (1000 or 3000 U/kg ...Daha fazlası

Makale 2009 Life Sciences84 ( 11.Dec ) , pp. 3 - 371 1072 Görüntülenme

Rosiglitazone treatment reduces hippocampal neuronal damage possibly through alleviating oxidative stress in chronic cerebral hypoperfusion

Özaçmak-Sayan, Hale | Özaçmak, Veysel Haktan | Barut, Figen | Jakubowska-Doğru, Ewa

Oxygen free radicals and lipid peroxidation may play significant roles in the progress of injury induced by chronic cerebral hypoperfusion of the central nervous system. Rosiglitazone, a well known activator of PPAR?, has neuroprotective properties in various animal models of acute central nervous system damage. In the present study, we evaluate the possible impact of rosiglitazone on chronic cerebral hypoperfused-rats in regard to the levels of oxidative stress, reduced glutathione, and hippocampal neuronal damage. Chronic cerebral hypoperfusion was generated by permanent ligation of both com ...Daha fazlası

Makale 2012 Neurochemistry International61 ( 3 ) , pp. 2 - 290 848 Görüntülenme

Beneficial effects of melatonin on reperfusion injury in rat sciatic nerve

Sayan, Hale | Özaçmak, Veysel Haktan | Özen, Oğuz Aslan | Coşkun, Ömer | Arslan, S. Oktay | Sezen, S. Cem | Aktaş, R. Gülhan

Studies have shown that ischemia-reperfusion (I/R) produces free radicals leading to lipid peroxidation and to damage of the nervous tissue. Melatonin, a main secretory product of the pineal gland, has free radical scavenging and antioxidant properties and has been shown to diminish I/R injury in many tissues. There are a limited number of studies related to the effects of melatonin on I/R injury in the peripheral nervous system. Therefore, in the present study, the protective effect of melatonin was investigated in rats subjected to 2 hr of sciatic nerve ischemia followed by 3 hr of reperfusi ...Daha fazlası

Makale 2004 Journal of Pineal Research37 ( 3 ) , pp. 1 - 148 1274 Görüntülenme

Chronic treatment with resveratrol, a natural polyphenol found in grapes, alleviates oxidative stress and apoptotic cell death in ovariectomized female rats subjected to chronic cerebral hypoperfusion

Özaçmak, Veysel Haktan | Özaçmak-Sayan, Hale | Barut, Figen

Objectives: Resveratrol appears to have neuroprotective potential in various animal models of brain disorders including cerebral ischemia and neurodegenerative diseases. Chronic cerebral hypoperfusion is a well-known pathological condition contributing to the neurodegenerative diseases such as vascular dementia. Purpose of the present study is to evaluate the possible therapeutic potential of resveratrol in a model of vascular dementia of ovariectomized female rats. Assessment of the potential was based on the determination of brain oxidative status, caspase-3 level, glial fibrillary acidic pr ...Daha fazlası

Makale 2016 Nutritional Neuroscience19 ( 4 ) , pp. 1 - 186 1080 Görüntülenme

Attenuation of contractile dysfunction by atorvastatin after intestinal ischemia reperfusion injury in rats

Özaçmak, Veysel Haktan | Sayan, Hale | Akyıldız-İğdem, Ayşenur | Çetin, Alpay | Özaçmak, İhsan Diler

Growing number of studies implicate that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, have beneficial effects on ischemia/reperfusion injury that are unrelated to their cholesterol-lowering action. In the present study, we aimed to evaluate possible effects of atorvastatin on oxidative stress, neutrophil accumulation, and contractile response of terminal ileum segments in rats subjected to intestinal ischemia/reperfusion. Intestinal ischemia/reperfusion model was generated by clamping the superior mesenteric artery for 30 min followed by reperfusion for 3 h. Oral adm ...Daha fazlası

Makale 2007 European Journal of Pharmacology562 ( 01.Feb ) , pp. 1 - 147 843 Görüntülenme

Erişime Açık

Overektomize dişi sıçanlarda beyin oksidatif stres, bdnf ve inflamatuar cevap düzeyleri ile nörodavranışsal değişiklikler üzerine anjiyotensin II İnhibisyonunun etkisi

Erdem, Salih

Menopoz overlerden hormon sekresyonunun azalması veya durması ile karakterize doğal fizyolojik bir süreçtir. Depresyon ve anksiyete menopozda en sık karşılaşılan semptomlardandır. Yapılan çalışmalar depresyon patogenezinde renin-anjiyotensin-aldesteron sisteminin, oksidatif stres hasarının, nörotrofik faktörlerin ve inflamatuar sitokinlerin kritik bir rol oynadığını göstermiştir. Biz bu çalışmada anjiyotensin II tip I reseptör blokerinin menopoz kaynaklı depresyon ve anksiyete benzeri nörodavranışlar üzerine etkisini araştırmayı ve olası etki mekanizmalarını beyin dokusunda nod-benzeri reseptö ...Daha fazlası

Master Tezi 2020 Sayan Özaçmak, Hale Zonguldak Bülent Ecevit Üniversitesi, Sağlık Bilimleri Enstitüsü, Fizyoloji Anabilim Dalı 701 Görüntülenme

Placental chorangiosis: The association with oxidative stress and angiogenesis

Barut A. | Barut F. | Kandemir N.O. | Aktunc E. | Arikan I. | Harma M. | Harma M.I.

Background/Aims: Chorangiosis is considered to be strongly associated with fetal, maternal, and placental disorders, and has been found to be correlated with increased fetal morbidity and mortality. In this study, it is aimed to investigate the association of angiogenesis and oxidative stress with the pathogenesis of chorangiosis. Methods: Expressions of heat shock protein 70 (HSP70), vascular endothelial growth factor-A (VEGF-A) and basic fibroblast growth factor (b-FGF), which are investigated with avidin-biotin-peroxidase method in formalin-fixed, paraffin-embedded sections from placental t ...Daha fazlası

Makale 2012 Gynecologic and Obstetric Investigation73 ( 2 ) , pp. 1 - 151 1038 Görüntülenme