Kucukebe, Omer Burak | Ozzeybek, Deniz | Abdullayev, Ruslan | Ustaoglu, Adil | Tekmen, Isli | Kume, Tuncay

Makale | 2017 | REVISTA BRASILEIRA DE ANESTESIOLOGIA67 ( 2 ) , pp.139 - 146

Purpose: Ischemia-reperfusion injury is one of the consequences of tourniquet application for extremity surgery. The aim of the study was to establish the effect of dexmedetomidine on the acute lung injury following lower extremity experimental ischemia-reperfusion model in rats. Methods: Twenty-eight Wistar-Albino breed rats were recruited after Ethics Committee approval and allocated into 4 groups, each with 7 subjects. Group 1 (SHAM) received only anesthesia. Group 2 (IR) had experienced 3 h of ischemia and 3 h of reperfusion using left lower extremity tourniquet after anesthesia application. Groups 3 (D-50) and 4 (D-100) had und . . .ergone the same procedures as in the Group 2, except for receiving 50 and 100 mg.kg(-1), respectively, dexmedetomidine intraperitoneally 1 h before the tourniquet release. Blood samples were obtained for the analysis of tumor necrosing factor-alpha and interleukin-6. Pulmonary tissue samples were obtained for histological analysis. Results: No significant difference regarding blood tumor necrosing factor -alpha and interleukin-6 values was found among the groups, whereas pulmonary tissue injury scores revealed significant difference. Histological scores obtained from the Group 2 were significantly higher from those in the Groups 1, 3 and 4 with p-values 0.001 for each comparison. Moreover, Group 1 scores were found to be significantly lower than those in the Groups 3 and 4 with p-values 0.001 and 0.011, respectively. No significant difference was observed between the Groups 3 and 4. Conclusion: Dexmedetomidine is effective in reduction of the experimental ischemia-reperfusion induced pulmonary tissue injury in rats, formed by extremity tourniquet application. (C) 2016 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda Daha fazlası Daha az

Özaçmak-Sayan, Hale | Özaçmak, Veysel Haktan | Turan, İnci | Barut, Figen | Hancı, Volkan

Makale | 2015 | REVISTA BRASILEIRA DE ANESTESIOLOGIA65 ( 6 ) , pp.483 - 490

Background and objectives: Serious functional and structural alterations of gastrointestinal tract are observed in failure of blood supply, leading to gastrointestinal dismotility. Activation of opioid receptors provides cardioprotective effect against ischemia-reperfusion (i/R) injury. The aim of the present study was to determine whether or not remifentanil could reduce i/R injury of small intestine. Methods: Male Wistar Albino rats were subjected to mesenteric ischemia (30 min) followed by reperfusion (3 h). Four groups were designed: sham control; remifentanil alone,i/R control; and remifentanit +1/R. Animals in remifentanit + i . . ./R group were subjected to infusion of remifentanil (2 ug kg-1 min-1) for 60 min, half of which started before inducing ischemia. Collecting the ileum tissues, evaluation of damage was based on contractile responses to carbachol, levels of lipid peroxidation and neutrophil infiltration, and observation of histopathological features in intestinal tissue. Results: Following reperfusion, a significant decrease in carbachol-induced contractile response, a remarkable increase in both lipid peroxidation and neutrophil infiltration, and a significant injury in mucosa were observed. An average contractile response of remifentanil + i/R group was significantly different from that of the i/R group. Lipid peroxidation and neutrophil infiltration were also significantly suppressed by the treatment. The tissue samples of the i/R group were grade 4 in histopathological evaluation. In remifentanil + i/R group, on the other hand, the mucosal damage was moderate, staging as grade 1. Conclusions: The pretreatment with remifentanil can attenuate the intestinal i/R injury at a remarkable degree possibly by lowering lipid peroxidation and leukocyte infiltration. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved Daha fazlası Daha az

Akin M. | Ayoglu H. | Okyay D. | Ayoglu F. | Gür A. | Can M. | Yurtlu S.

Makale | 2015 | Revista Brasileira de Anestesiologia65 ( 1 ) , pp.51 - 60

Background and objectives: In this study, we aimed to investigate the effects of sevoflurane, desflurane and propofol maintenances on serum levels of selenium, copper, zinc, iron, malondialdehyde, and glutathion peroxidase measurements, and antioxidant capacity. Methods: 60 patients scheduled for unilateral lower extremity surgery which would be performed with tourniquet under general anesthesia were divided into three groups. Blood samples were collected to determine the baseline serum levels of selenium, copper, zinc, iron, malondialdehyde and glutathion peroxidase. Anesthesia was induced using 2-2.5 mg kg-1 propofol, 1 mg kg-1 li . . .docaine and 0.6 mg kg-1 rocuronium. In the maintenance of anesthesia, under carrier gas of 50:50% O2:N2O 4Lmin-1, 1 MAC sevoflorane was administered to Group S and 1 MAC desflurane to Group D; and under carrier gas of 50:50% O2:air 4 L min-1 6 mg kg h-1 propofol and 1µg kg h-1 fentanyl infusion were administered to Group P. At postoperative blood specimens were collected again. Results: It was observed that only in Group S and P, levels of MDA decreased at postoperative 48th hour; levels of glutathion peroxidase increased in comparison to the baseline values. Selenium levels decreased in Group S and Group P, zinc levels decreased in Group P, and iron levels decreased in all three groups, and copper levels did not change in any groups in the postoperative period. Conclusion: According to the markers of malondialdehyde and glutathion peroxidase, it was concluded that maintenance of general anesthesia using propofol and sevoflurane activated the antioxidant system against oxidative stress and using desflurane had no effects on oxidative stress and antioxidant system. © 2014 Sociedade Brasileira de Anestesiologia Daha fazlası Daha az

Yurtlu B.S. | Hanci V. | Köksal B. | Okyay D. | Ayoğlu H. | Turan I.T.

Makale | 2015 | Brazilian Journal of Anesthesiology65 ( 6 ) , pp.455 - 460

Objetivo: Métodos: Resultados: Conclusão: Objective: We have planned to evaluate the laryngeal mask cuff pressures (LMcp) inflated by anesthesia workers of several seniority, without using manometer. Methods: 180 patients scheduled to have short duration surgery with laryngeal mask were included in the study. Five anesthesia specialists (Group S), 10 residents (Group R) and 6 technicians (Group T) inflated the LMc; thereafter LMcp were measured with pressure manometer. Participants have repeated this practice in at least five different cases. LMcp higher than 60cm H2O at the initial placement or intraoperative period were adjusted t . . .o normal range. Sore throat was questioned postoperatively. Groups were compared in terms of mean LMcp and occupational experience. Results: At the settlement of LM, LMcp pressures within the normal range were determined in 26 (14.4%) cases. Mean LMcp after LM placement in Group S, R and T were 101.2±14.0, 104.3±20.5cm H2O and 105.2±18.4cm H2O respectively (p>0.05). Mean LMcp values in all measurement time periods within the groups were above the normal limit (60cm H2O). When groups were compared in terms of LMcp, no difference has been found among pressure values. Occupational experience was 14.2±3.9; 3.3±1.1 and 6.6±3.8 years for specialists, residents and technicians respectively and measured pressure values were not different in regard of occupational experience. Seven (3.9%) patients had sore throat at the 24th hour interview. Conclusion: Considering lower possibility of normal adjustment of LMcp and ineffectiveness of occupational experience to obtain normal pressure values, it is suitable that all anesthesia practitioners should adjust LMcp with manometer. © 2013 Sociedade Brasileira de Anestesiologia Daha fazlası Daha az

Isik, Hatice | Isik, Metin | Aynioglu, Oner | Karcaaltincaba, Deniz | Sahbaz, Ahmet | Beyazcicek, Tugba | Harma, Mehmet Ibrahim

Makale | 2017 | REVISTA BRASILEIRA DE REUMATOLOGIA57 ( 3 ) , pp.210 - 216

Objective: Females with Sjogren's Syndrome (SS) often experience vaginal dryness and dyspareunia, along with glandular and extraglandular symptoms. We aimed to evaluate sexual function and life quality in women with SS. Methods: Forty-six premenopausal women with SS and 47 age-matched controls were studied. Age, duration of the disease, medications, and comorbid diseases were noted. Participants completed 36-Item Short Form Health Survey (SF-36) and Female Sexual Function Index (FSFI). Patients were asked about vaginal discharge and itching in the last month, and if they informed their rheumatologists about any sexual problems. Gyne . . .cologic examinations were performed and vaginal smears were taken on each participant. Results: The median total scores of FSFI were significantly lower in the SS group than the controls [17.12 (2.4-27.8) and 27.4 (16.9-36.0), respectively, p < 0.001]. In the SS group, 37 (80.4%) and in the control group 18 (38.3%) of patients were sexually dissatisfied (p < 0.001). Vaginal dryness and lubricant use were significantly increased in patients with SS compared to controls (p < 0.001). Life quality scores were significantly lower in patients with SS than the controls (p < 0.001). Vaginal dryness was negatively correlated with FSFI total (r = -0.312, p = 0.035) and subscores except desire and arousal. Physical functioning, role physical and role emotional scores were positively correlated with total FSFI scores (r = 0.449, p = 0.002, r = 0.371, p = 0.011, r = 0.299, p = 0.043, respectively). Conclusions: Women with SS experience less satisfaction with sexual activity, which can be affected by age, vaginal dryness, physical pain, and impaired function due to the disease. Therefore, rheumatologists should pay attention to these symptoms and management. (C) 2017 Elsevier Editora Ltda Daha fazlası Daha az

Hanci V. | Gülle K. | Karakaya K. | Yurtlu S. | Akpolat M. | Yüce M.F. | Yüce F.Z.

Makale | 2015 | Revista Brasileira de Anestesiologia65 ( 1 ) , pp.1 - 6

Background and objectives: In this study, we investigated the anesthetic and mucosal effects of the rectal application of dexmedetomidine to rats. Methods: Male Wistar albino rats weighing 250-300g were divided into four groups: Group S (n=8) was a sham group that served as a baseline for the normal basal values; Group C (n=8) consisted of rats that received the rectal application of saline alone; Group IPDex (n=8) included rats that received the intraperitoneal application of dexmedetomidine (100 µg kg-1); and Group RecDex (n=8) included rats that received the rectal application of dexmedetomidine (100 µg kg-1). For the rectal drug . . . administration, we used 22G intravenous cannulas with the stylets removed. We administered the drugs by advancing the cannula 1cm into the rectum, and the rectal administration volume was 1mL for all the rats. The latency and anesthesia time (min) were measured. Two hours after rectal administration, 75 mg kg-1 ketamine was administered for intraperitoneal anesthesia in all the groups, followed by the removal of the rats' rectums to a distal distance of 3cm via an abdominoperineal surgical procedure. We histopathologically examined and scored the rectums. Results: Anesthesia was achieved in all the rats in the Group RecDex following the administration of dexmedetomidine. The onset of anesthesia in the Group RecDex was significantly later and of a shorter duration than in the Group IPDEx (p < 0.05). In the Group RecDex, the administration of dexmedetomidine induced mild-moderate losses of mucosal architecture in the colon and rectum, 2 h after rectal inoculation. Conclusion: Although 100µgkg-1 dexmedetomidine administered rectally to rats achieved a significantly longer duration of anesthesia compared with the rectal administration of saline, our histopathological evaluations showed that the rectal administration of 100µgkg-1 dexmedetomidine led to mild-moderate damage to the mucosal structure of the rectum. © 2013 Sociedade Brasileira de Anestesiologia Daha fazlası Daha az

Yurtlu, Bulent Serhan | Hanci, Volkan | Koksal, Bengu | Okyay, Dilek | Ayoglu, Hilal | Turan, Isil Ozkocak

Makale | 2015 | REVISTA BRASILEIRA DE ANESTESIOLOGIA65 ( 6 ) , pp.455 - 460

Objective: We have planned to evaluate the laryngeal mask cuff pressures (LMcp) inflated by anesthesia workers of several seniority, without using manometer. Methods: 180 patients scheduled to have short duration surgery with laryngeal mask were included in the study. Five anesthesia specialists (Group S), 10 residents (Group R) and 6 technicians (Group T) inflated the LMc; thereafter LMcp were measured with pressure manometer. Participants have repeated this practice in at least five different cases. LMcp higher than 60 cm H2O at the initial placement or intraoperative period were adjusted to normal range. Sore throat was questione . . .d postoperatively. Groups were compared in terms of mean LMcp and occupational experience. Results: At the settlement of LM, LMcp pressures within the normal range were determined in 26 (14.4%) cases. Mean LMcp after LM placement in Group S, R and T were 101.2 +/- 14.0, 104.3+/-20.5 cm H2O and 105.2 18.4 cm H2O respectively (p >0.05). Mean LMcp values in all measurement time periods within the groups were above the normal limit (60 cm H2O). When groups were compared in terms of LMcp, no difference has been found among pressure values. Occupational experience was 14.2 3.9; 3.3 1.1 and 6.6 3.8 years for specialists, residents and technicians respectively and measured pressure values were not different in regard of occupational experience. Seven (3.9%) patients had sore throat at the 24th hour interview. Conclusion: Considering lower possibility of normal adjustment of LMcp and ineffectiveness of occupational experience to obtain normal pressure values, it is suitable that all anesthesia practitioners should adjust LMcp with manometer. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved Daha fazlası Daha az

Erdivanli, Basar | Altun, Murat | Sezen, Ozlem K. | Colakoglu, Serhan A.

Makale | 2013 | REVISTA BRASILEIRA DE ANESTESIOLOGIA63 ( 2 ) , pp.183 - 187

WOS: 000330124300004

Pişkin O. | Küçükosman G. | Altun D.U. | Çimencan M. | Özen B. | Aydin B.G. | Okyay R.D.

Makale | 2016 | Brazilian Journal of Anesthesiology66 ( 4 ) , pp.376 - 382

Background and objective: Sugammadex is the first selective relaxant binding agent. When compared with neostigmine, following sugammadex administration patients wake earlier and have shorter recovery times. In this study, we hypothesized that fast and clear awakening in patients undergoing general anesthesia has positive effects on cognitive functions in the early period after operation. Methods: Approved by the local ethical committee, 128 patients were enrolled in this randomized, prospective, controlled, double-blind study. Patients were allocated to either Sugammadex group (Group S) or the Neostigmine group (Group N). The primar . . .y outcome of the study was early postoperative cognitive recovery as measured by the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE). After baseline assessment 12-24 h before the operation. After the operation, when the Modified Aldrete Recovery Score was ?9 the MMSE and 1 h later the MoCA tests were repeated. Results: Although there was a reduction in MoCA and MMSE scores in both Group S and Group N between preoperative and postoperative scores, there was no statistically significant difference in the slopes (p > 0.05). The time to reach TOF 0.9 was 2.19 min in Group S and 6.47 min in Group N (p < 0.0001). Recovery time was 8.26 min in Group S and 16.93 min in Group N (p < 0.0001). Conclusion: We showed that the surgical procedure and/or accompanying anesthetic procedure may cause a temporary or permanent regression in cognitive function in the early postoperative period. However, better cognitive performance could not be proved in the Sugammadex compared to the Neostigmine. © 2015 Sociedade Brasileira de Anestesiologia Daha fazlası Daha az