Kalem, Mahmut | Sahin, Ercan | Songur, Murat | Keser, Scicuk | Kinik, Hakall

Article | 2018 | ACTA ORTHOPAEDICA BELGICA84 ( 2 ) , pp.203 - 212

This study aimed to compare the results of AP screws, PA screws and posterior buttress plate used in posterior malleolar fixation of trimalleolar fractures. In this study, the data of 104 trimalleolar fracture cases treated surgically between October 2011 and January 2014 were extracted from hospital records. Patient demographics (age, gender, body mass index), the presence of syndesmotic injury, fracture type (according to the Lauge-Hansen classification), the size of posterior malleolar fragment (measured on lateral radiographs) were recorded. The patients requiring postoperative care for at least a year were invited to attend an . . .evaluation of functional and radiological outcomes. At the final follow-up examination the functional evaluation was made by using AOFAS scores, VAS scores during walking, and dorsiflexion restrictions as compared with the unaffected side. As for the radiological evaluation, the patients were assessed according to the presence of a gap or step by the direct use of graphies following the fixation and with regard to the osteoarthritic development in alignment with the Bargon criteria. A total of 67 patients met the study inclusion criteria; 20 cases in the AP screw, 13 cases in the PA screw and 34 cases in the plate group. The mean follow-up period was 14.4 +/- 2.23 months in AP, 16.3 +/- 2.56 months in PA and 17.1 +/- 3.01 months in the plate group. Better AOFAS scores were obtained in the PA group and the plate group compared to the AP screw group (p < 0.001). No statistically significant difference was found between the groups in respect of VAS scores during walking and dorsiflexion restriction. Better radiological reduction was observed in the PA screw group and the plate group (p < 0.001). PA screw and posterior buttress plate fixation with direct reduction via posterolateral approach demonstrated better radiological and functional outcomes than AP screw fixation Daha fazlası Daha az

Aronsson, Anna | Guler, Fatma | Petoukhov, Maxim V. | Crennell, Susan J. | Svergun, Dmitri I. | Linares-Pasten, Javier A. | Karlsson, Eva Nordberg

Article | 2018 | BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS1866 ( 2 ) , pp.292 - 306

Hydrolysis of arabinoxylan (AX) by glycoside hydrolase family 10 (GH10) xylanases produces xylo-and arabinoxylo-oligosaccharides ((A)XOS) which have shown prebiotic effects. The thermostable GH10 xylanase RmXyn10A has shown great potential to produce (A)XOS. In this study, the structure of RmXynlOA was investigated, the catalytic module by homology modelling and site-directed mutagenesis and the arrangement of its five domains by small-angle X-ray scattering (SAXS). Substrate specificity was explored in silico by manual docking and molecular dynamic simulations. It has been shown in the literature that the glycone subsites of GH10 x . . .ylanases are well conserved and our results suggest that RmXyn10A is no exception. The aglycone subsites are less investigated, and the modelled structure of RmXyn10A suggests that loop alpha(6)beta(6) in the aglycone part of the active site contains a non-conserved alpha-helix, which blocks the otherwise conserved space of subsite + 2. This structural feature has only been observed for one other GH10 xylanase. In RmXyn10A, docking revealed two alternative binding regions, one on either side of the alpha-helix. However, only one was able to accommodate arabinose-substitutions and the mutation study suggests that the same region is responsible for binding XOS. Several non-conserved structural features are most likely to be responsible for providing affinity for arabinose-substitutions in subsites +1 and + 2. The SAXS rigid model of the modular arrangement of RmXyn10A displays the catalytic module close to the cell-anchoring domain while the carbohydrate binding modules are further away, likely explaining the observed lack of contribution of the CBMs to activity Daha fazlası Daha az

Bilgici, Meltem Ceyhan | Bekci, Tumay | Ulus, Yasemin | Bilgici, Ayhan | Tomak, Leman | Selcuk, Mustafa Bekir

Article | 2018 | JOURNAL OF MEDICAL ULTRASONICS45 ( 1 ) , pp.137 - 141

Our objective in this study was to assess the changes in medial gastrocnemius muscle (GCM) stiffness after botulinum toxin A (BTA) injection in children with cerebral palsy (CP) by using acoustic radiation force impulse (ARFI) elastography and to research the usability of this technique in clinical practice. Twenty-four spastic lower extremities of 12 children with CP were assessed. BTA injection treatment was applied to the medial GCM. Muscle stiffness was measured with the ARFI technique before the procedure and a month after the procedure. The patients were assessed with the modified Ashworth scale (MAS) in the physiotherapy depa . . .rtment at about the same time. Shear wave velocity (SWV) values and MAS scores before and after the treatment were compared. Mean SWV values were measured as 3.20 +/- 0.14 m/s before BTA and as 2.45 +/- 0.21 m/s after BTA, and the difference between them was found to be statistically significant (p < 0.001). Mean MAS score (2.33 +/- 0.70) after BTA decreased significantly when compared to the score before BTA (2.96 +/- 0.62) (p = 0.001). SWV values positively correlated with MAS scores (rho = 0.578, p = 0.003). The interobserver agreement expressed as interclass correlation coefficient (ICC) was 0.65 (95% CI 0.33-0.84, p < 0.001). ARFI elastography for identifying structural changes that occur in the spastic muscle after BTA injection in children with CP can yield more valuable information with combined use of MAS Daha fazlası Daha az

Karauzum, Kurtulus | Karauzum, Irem | Ural, Dilek | Baydemir, Canan | Aktas, Mujdat | Celikyurt, Umut | Kozdag, Guliz

Article | 2018 | ACTA CARDIOLOGICA73 ( 2 ) , pp.164 - 170

Objective: The risk stratification for prognosis in heart failure is very important for optimal disease management and decision making. The aim of this study was to establish a simple discharge 1-year mortality prediction model by integrating data obtained from demographic characteristics, clinical evaluation, laboratory biomarkers and echocardiographic evaluation of hospitalised heart failure with reduced ejection fraction (HFrEF) patients with acute decompensation. Methods and results: A risk score model was developed based on beta-coefficient number of variables in a multivariable logistic regression model which was created with . . .the use of data on clinical, laboratory, imaging and therapeutic findings of 670 patients (65.4% males, 65 +/- 11 years) who was hospitalised with acute decompensated HFrEF. The mean left ventricular ejection fraction (LVEF) was 26 +/- 9%. Independent predictors of mortality were: age >= 75 years, sodium Daha fazlası Daha az

Ozturk, Mesut | Aslan, Serdar | Saglam, Dilek | Bekci, Tumay | Bilgici, Meltem Ceyhan

Article | 2018 | EURASIAN JOURNAL OF MEDICINE50 ( 1 ) , pp.56 - 58

Epiploic appendagitis, caused by inflammation of small adipose tissue on the colon wall, is a rare cause of acute abdominal pain in the pediatric population. It is nearly impossible to establish a specific diagnosis merely on the basis of clinical findings; thus, radiological evaluation is always necessary. In this report, we present the cases of three children with abdominal pain who were diagnosed with epiploic appendagitis. All cases were successfully treated with conservative management.

Polat, Ceylan | Sironen, Tarja | Plyusnina, Angelina | Karatas, Ahmet | Sozen, Mustafa | Matur, Ferhat | Vapalahti, Olli

Article | 2018 | JOURNAL OF MEDICAL VIROLOGY90 ( 5 ) , pp.810 - 818

Hantaviruses infect humans via inhalation of viral particles within secretions of infected rodents or rarely through direct contact with infected rodents. Determining the prevalence of hantavirus infections among rodent populations is of vital importance to obtain information on hantavirus-related cases and to predict possible outbreaks. We hypothesized that DOBV strains circulating in the Thrace Region in Turkey would be related to other Balkan DOBV strains. In this study, hantavirus infections in the rodent population of the Krklareli-neada Region (north-western Turkey, near the Bulgarian border) were investigated. This region is . . .of particular importance, as it is located in the south-eastern margin of the European continent and was used as an entrance point of Asian faunal elements into Europe. DOBV infection was detected in eight of 73 rodents; all were of the Apodemus flavicollis species. Partial sequences of the viral S-, M-, and L-genome segments were recovered and compared with previously reported DOBV sequences. The newly characterized Turkish strains were similar to other DOBV variants. Silent nucleotide mutations were dominant. The hantavirus prevalence in the neada region was similar to what has been reported in Greece and Bulgaria. For the first time, the M-segment sequences of DOBV from Turkey were recovered and genetic data of hantaviruses from Thrace region of Turkey were obtained Daha fazlası Daha az

Oral, Keziban | Akan, Mert | Ozkardesler, Sevda | Boztas, Nilay | Ergur, Bekir Ugur | Guneli, Mehmet Ensari | Olguner, Cimen

Article | 2018 | TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION46 ( 6 ) , pp.453 - 461

Objective: One of the methods that can be used to prevent ischaemia reperfusion (IR) injury is ischaemic preconditioning. The aim of this study was to evaluate and compare the effects of remote and direct ischaemic preconditioning (RIPC and DIPC) histopathologically in the rat renal IR injury model. Methods: After obtaining an approval from the Dokuz Eylul University School of Medicine Ethics Committee, 28 Wistar Albino male rats were divided into four groups. In Group I (Sham, n=7), laparotomy and left renal pedicle dissection were performed, but nothing else was done. In Group II (IR, n=7), after 45 minutes of left renal pedicle o . . .cclusion, reperfusion lasting 4 hours was performed. In Group III (DIPC+IR, n=7), after four cycles of ischaemic preconditioning applied to the left kidney, renal IR was performed. In Group IV (RIPC+IR, n=7), after three cycles of ischaemic preconditioning applied to the left hind leg, renal IR was performed. All rats were sacrificed, and the left kidney was processed for conventional histopathology. Results: The histopathological injury score of the kidney was significantly lower in the sham group compared with the other groups ( Daha fazlası Daha az

Yılmaz, Öznur

Master Thesis | 2018 | Bülent Ecevit Üniversitesi Sağlık Bilimleri Enstitüsü, Çocuk Sağlığı ve Hastalıkları Hemşireliği Anabilim Dalı

Oyun döneminden sonra gelen okul öncesi dönem; çocukların biraz daha sosyalleşip grup ve sembolik oyunları ortak gerçekleştirdiği bir dönemdir. Bu yaş grubu çocukların sosyalleşmesini geciktiren önemli bir neden ayrılık kaygısıdır.Oyunun etkili olarak kullanıldığı oyun terapi bu çocuklarda sorunun çözümlenmesinde önemli bir yere sahiptir. Araştımanın amacı; okul öncesi çocuklarda oyun terapisinin ayrılık kaygısı üzerine etkisini değerlendirmektir. Araştırma ön test-son test kontrol gruplu deneysel bir çalışmadır. Araştırmanın evrenini, Kozlu Merkez Anaokulu ve Kozlu Fatih Anaokulu'nda eğitim gören 3-5 yaş grubu 292 okul öncesi çocuk . . . oluşturmuştur. Power analizine göre hesaplanan örneklem büyüklüğü deney grubunda 30; kontrol grubunda 30 toplam 60 okul öncesi çocuk üzerinde yapılmıştır. Verilerin toplanmasında; demografik bilgi formu, yeniden düzenlenen okul öncesi kaygı ölçeği ve yuva çocukları için ayrılma kaygı ölçeği (öğretmen formu) kullanılmıştır. Yuva çocukları için ayrılma kaygı ölçeği toplam puan ortalaması eğitim öncesi ve eğitim sonrası kendi aralarındaki değişim değerlendirildiğinde; deney grubunda olan çocukların eğitim sonrası ayrılık kaygısındaki düşüş kontrol grubuna göre daha fazladır. Her iki grupta da ayrılık kaygısındaki düşüş istatistiksel olarak anlamlı bulunmuştur ( Daha fazlası Daha az

Erem, Fundagül | Certel, Muharrem

Article | 2018 |

Bu çalışmada daha önceki bir çalışmada sünmüş ekmeklerden izole edilen 14 adet Bacillus suşunun, 30 °C, 37 °C, 50 °C ve 55 °C’de peptidaz üretme potansiyellerinin belirlenmesinin ardından, peptidaz aktivitesi en yüksek olan iki suş için en uygun enzim üretim besiyeri bileşimi ve koşullarının bir kerede bir faktör yaklaşımı ile optimizasyonu yapılmıştır. Bu amaçla en iyi aktivite değerini sağlayan karbon ve azot kaynağı ile karbon/azot oranı, çalkalama hızı ve ön kültür besiyeri seçimi maliyet unsuru da göz önünde bulundurularak tespit edilmiştir. En iyi karbon ve azot kaynağının sırasıyla glukoz ve maya ekstraktı olduğu saptanmıştır . . .. Ayrıca karbon/azot oranının 1:5, çalkalama hızının 250 rpm olması durumunda ve ön kültür hazırlanması için enzim üretim ortamı ile aynı besiyeri kullanıldığında daha yüksek peptidaz aktivitesi değeri elde edilmiştir Daha fazlası Daha az

Kajama, Mohammed Nasir | Yıldırım, Yılmaz | Taura, Usman Habu | Grema, Alhaji Shehu | Abdulrahman, Shehu

Article | 2018 | NANO HYBRIDS AND COMPOSITES21 , pp.43 - 52

A dip-coating technique was applied to prepare a selective membrane on a commercial ceramic mesoporous support. Single gas components used for permeance and selectivity were CH4, CO2, H-2, He, N-2, and O-2 (BOC UK) with at least 99.999 (% v/v) purity. The permeances and selectivities were obtained at room temperature and transmembrane pressure differences between 0.05 up to 5.0 barg. Gas permeation experiments showed the permeance of CO2 to be strongly influenced by surface diffusion mechanism. Single gas experiment showed linear flow dependence on the inverse square root of molecular weight at room temperature and 1.0 barg. The sin . . .gle gas selectivities were found to be higher than the ideal Knudsen separation mechanism. The highest CO2/CH4 selectivity value of 24.07 was obtained at 0.7 barg and room temperature Daha fazlası Daha az

Hakyemez, I. N. | Erdem, H. | Beraud, G. | Lurdes, M. | Silva-Pinto, A. | Alexandru, C. | Bishop, B.

Düzeltme | 2018 | EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES37 ( 7 ) , pp.1241 - 1242

In the original version of this article, Mustafa Sunbul was not included in the list of authors for this article. The name has been added accordingly.

Gonca, Ersoz | Catli, Duygu

Article | 2018 | TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION46 ( 6 ) , pp.447 - 452

Objective: Bupivacaine, a local anaesthetic substance, is used as a regional-anaesthesia agent. Lidocaine, a sodium channel blocker, is used in combination with epinephrine for regional anaesthesia. We aimed to evaluate the effects of lidocaine with epinephrine (LE) at different doses on bupivacaine-induced cardiotoxicity in rats. Methods: In our study, 24 Wistar albino rats were divided into four groups: I) Control; II) LE, 1 mg kg(-1); III) LE, 3 mg kg(-1) and IV) LE, 6 mg kg(-1). Intravenous bupivacaine was administered at a dose of 3 mg kg(-1) min(-1) to the anaesthetized rats in all groups until cardiac asystole was achieved. L . . .E was administered at the doses of 1, 3 and 6 mg kg(-1) min(-1) using infusion, simultaneously with bupivacaine. The asystole time and 75% decrement time in mean arterial blood pressure (MABP) were determined. P-Q, Q-T and QRS intervals were measured using electrocardiography (ECG) recordings. Results: LE significantly increased the asystole time and 75% decrement time in MABP at the doses of 3 and 6 mg kg(-1) compared to the control group ( Daha fazlası Daha az