Panhwar, Abdul Haleem | Tüzen, Mustafa | Hazer, Baki | Kazi, Tasneem Gul

Article | 2018 | Talanta184 , pp.115 - 121

A simple, rapid and sensitive solid phase microextraction method was used for the speciation of inorganic antimony (Sb) by using a novel synthesized polymeric material in micropipette tip of syringe system. In present methodology, the specie of Sb (III) made hydrophobic complex with diethyl dithiocarbamate (DDTC) at pH 5.5 and subsequently adsorbed on polystyrene oleic acid imidazole polymer (POIP), whereas Sb(V) did not made complex and adsorbed on the polymer, remained in aqueous solutions. The strategy of multivariate was carried out to screen out the different variables and assessed the optimum values of their experimental value . . .s for the extraction efficiency of analyte. Then the analyte was sorbed on the polymer in micropipette tip of syringe system was quantitatively eluted by different types of acids at different levels for 2–6 aspirating/dispensing cycles. The extracted Sb(III) ions with modifiers were directed into the graphite furnace atomic absorption spectrometry for analysis. The limit of detection (LOD), limit of quantification (LOQ) and preconcentration factor (PF) for Sb(III) was found to be 6 ng L-1, 20 ng L-1 and 100. The RSD value was found to be 4.2%. The standard addition method and certified reference materials were checked for accuracy and validity of method. The developed method was effectively applied for the determination of total and inorganic species of Sb(III) and Sb(V) in different types of water samples, whereas only total Sb was determined in acid digested soil, Tuna fish, rice, spinach, black tea, mixed fruit juice and ice tea samples. © 2018 Elsevier B.V Daha fazlası Daha az

Öztürk, Temel | Kılıçlıoğlu, Ali | Savaş, Bedrettin | Hazer, Baki

Article | 2018 | Journal of Macromolecular Science, Part A: Pure and Applied Chemistry55 ( 8 ) , pp.588 - 594

The synthesis of poly(?-caprolactone-co-ethylene glycol) AAB star-type amphiphilic copolymers were carried out by use of a “click” chemistry reaction to block propargyl polyethylene glycol (propargyl-PEG) to terminally azide poly(?-caprolactone) (PCL-N3). For this purpose, propargyl-PEG was synthesized by the reaction of PEGs (3000 Da, 2000 Da, 1500 Da, and 1000 Da) and propargyl chloride. Terminally chloride poly(?-caprolactone) (PCL-Cl) was carried out by means of ring-opening polymerization (ROP) of ?-caprolactone (CL) and 3-chloro-1,2-propanediol. Synthesis of PCL-N3 was obtained by the chemical interaction of PCL-Cl and sodium . . .azide. By reacting propargyl-PEG and PCL-N3, the star-type amphiphilic copolymers were obtained. The characterization of products was accomplished by using multiple instruments including 1H-NMR, FT-IR, GPC, TGA, contact angles, and elemental analysis techniques. © 2018, © 2018 Taylor & Francis Group, LLC Daha fazlası Daha az

Zounr, Rizwan Ali | Tüzen, Mustafa | Hazer, Baki | Khuhawar, Muhammad Yar

Article | 2018 | FOOD ANALYTICAL METHODS11 ( 9 ) , pp.2538 - 2546

A new solid-phase microextraction (SP mu E) procedure has been developed for separation and preconcentration of Sn ions by using graphite furnace atomic absorption spectrometry (GFAAS). This technique is based on the complexation of Sn(IV) ions with 1-(2-pyridylazo)-2-naphthol (PAN). The poly (epsilon-caprolactone-b-4-vinyl benzyl-g-dimethyl amino ethyl methacrylate) polymer (PCL vacr) was used as an adsorbent, and it was loaded in micropipette tip of syringe system. Sn(IV) ions were adsorbed on polymer at pH 6. Different experimental conditions were optimized such as pH, amount of complexing agent, and amount of adsorbent. The dete . . .ction limit (LOD), limit of quantification, preconcentration factor (PF), and relative standard deviation (RSD) were found as 4.5 ng L-1, 13.5 ng L-1, 100, and 3.3%, respectively. Certified reference materials were used to confirm the accuracy of the investigated procedure, and the procedure was successfully practiced for determination of entire concentration of tin within beverages and different food samples Daha fazlası Daha az

Can, Ahmet | Sivrikaya, Hüseyin | Hazer, Baki

Article | 2018 | International Biodeterioration and Biodegradation133 , pp.210 - 215

In this study, Scots pine (Pinus sylvestris L.) samples were impregnated with autoxidized soybean oil polymer containing Ag nanoparticles (Agsbox) and polystyrene-soybean oil copolymer (AgPSsb) in order to inhibit white-rot fungus (Trametes versicolor). Chemical changes of the impregnated specimens were characterized by FTIR techniques. The higher concentration of nano preservative resulted in higher weight percent gain (WPG) in the impregnated samples. The samples impregnated with 1.5% of Agsbox, had the highest WPG (2.98%). The silver nanocomposite-impregnated wood specimens improved the anti-fungal properties. In addition, treatm . . .ent with 0.4% AgPSsb resulted in the lowest moisture content (23.4%) after decay tests. In the samples, the lowest weight loss (0.87%) due to fungal decay was observed with the use of 0.4 wt% of AgPSsb. Mass losses of Agsbox impregnated specimens at 1.5% and 0.04% were 2.86% and 4.61% respectively. The FTIR spectra of the specimens impregnated with the nanocomposites showed the impregnated components at the peaks of 2910 cm-1 and 1714 cm-1 in particular. © 2018 Elsevier Lt Daha fazlası Daha az

Karahaliloğlu, Zeynep | Kılıçay, Ebru | Alpaslan, Pınar | Hazer, Baki | Denkbaş, Emir Baki

Article | 2018 | JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS33 ( 1 ) , pp.38 - 62

The development of novel combination anticancer drug delivery systems is an important step to improve the effectiveness of anticancer treatment in metastatic breast cancer and to overcome increased toxicity of the currently used combination treatments. The aim of this study was to assess efficient targeting, therapeutic efficacy, and bioavailability of a combination of drugs (curcumin and -tocopheryl succinate) loaded polystyrene-polysoyaoil-diethanol amine nanoparticles. Polystyrene-polysoyaoil-diethanol amine nanoparticles encapsulating two drugs, individually or in combination, were prepared by double-emulsion solvent evaporation . . . method, resulting in particle size smaller than 250nm with a surface negative charge between -30 and -40mV. Entrapment efficiency of curcumin and -tocopheryl succinate in the epigallocatechin gallate-conjugated dual-drug-loaded nanoparticles was found to be 68% and 80%, respectively. The release kinetics of curcumin and -tocopheryl succinate from the nanoparticles exhibited a gradual and continuous profile followed by an initial burst behavior with a release over 20days in vitro. Next, we have investigated the anticancer activity of nanoparticles encapsulating both the drugs and individually drug in human breast cancer cells (MDA-MB-231) using double-staining-based cell death analysis, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assessment of cytotoxicity and flow cytometer. In vitro cytotoxicity studies revealed that epigallocatechin gallate--tocopheryl succinate/curcumin-polystyrene-polysoyaoil-diethanol amine nanoparticles are more potent than the corresponding -tocopheryl succinate/curcumin-polystyrene-polysoyaoil-diethanol amine nanoparticles and their single-drug-loaded forms and show a synergistic and breast tumor targeting function. Thus, here, we propose epigallocatechin gallate-conjugated curcumin and -tocopheryl succinate-loaded polystyrene-polysoyaoil-diethanol amine nanoparticles which effectively inhibit tumor growth and reduce toxicity compared to single-drug chemotherapy Daha fazlası Daha az

Aydın Tığlı, R. Seda | Akyol, Elvan | Hazer, Baki

Article | 2018 | Journal of Polymers and the Environment26 ( 3 ) , pp.1262 - 1271

Controlling the degradation parameters is one of the main challenges of preparing appropriate biomaterials for biomedical applications. In this study, the effect of soybean oil inclusion on hydrolytic degradation of polylactic acid (PLA) was investigated both in vitro and in vivo. PLA/oil membranes were prepared by using polymeric soybean oil (PSO), epoxidized soybean oil and soybean oil (SOYA) with their varied concentrations. Degradation of membranes was performed in vitro for 8 weeks period and in vivo for 4 weeks period. Weight loss, changes in molecular weight, thermal properties and morphological changes were studied during de . . .gradation. SOYA blended PLA membranes show the lowest degradation rates by bulk degradation after 4 weeks in vitro, followed by surface erosion for the first week. Approximately twofold high percentage weight losses of all membranes were obtained after 4 weeks of degradation in vivo in comparison with in vitro data. The significant weight loss, molecular weight loss and thermal property change for PSO blended membranes were determined during in vivo degradation which highlights the increase of degradation rate by bulk degradation. Drastic morphological changes were observed on surface of degraded membranes in vivo with large pores, cracks, fissures and large cavities. © 2017, Springer Science+Business Media New York Daha fazlası Daha az